Table 3. The associations between plasma miRNA levels over time with patient characteristics.

	miR125b†		miR141†		miR16†		miR17-3p†		miR200b†		miR29a†		miR31†		miR92a†
	Estimate§ (95% CI)	P-val	Estimate (95% CI)	P-val	Estimate (95% CI)	P-val	Estimate (95% CI)	P-val	Estimate (95% CI)	P-val	Estimate (95% CI)	P-val	Estimate (95% CI)	P-val	Estimate (95% CI)	P-val
Intercept	10.54 (9.68, 11.4)		9.5 (7.03, 11.96)		15.38 (14.62, 16.13)		8.96 (7.95, 9.96)		9.65 (8.26, 11.03)		13.59 (12.75, 14.43)		8.56 (7.57, 9.56)		15.81 (14.95, 16.66)
Age		0.03		0.19		0.13		0.09		0.08		0.26		0.40		0.28
⩾56	−0.45 (−0.87, −0.04)		0.93 (−0.66, 2.52)		−0.29 (−0.66, 0.09)		−0.44 (−0.93, 0.06)		−0.62 (−1.32, 0.07)		−0.24 (−0.65, 0.18)		−0.21 (−0.74, 0.32)		−0.23 (−0.65, 0.19)
<56a
Gender		0.37		0.93		0.55		0.46		0.17		0.42		0.97		0.91
Male	−0.19 (−0.62, 0.23)		0.06 (−1.65, 1.77)		0.12 (−0.26, 0.49)		−0.19 (−0.7, 0.31)		−0.5 (−1.21, 0.21)		−0.17 (−0.59, 0.25)		−0.01 (−0.49, 0.47)		0.02 (−0.4, 0.45)
Femalea
Race		0.78		0.61		0.91		0.73		0.74		0.23		0.31		0.87
White	0.09 (−0.55, 0.73)		−0.45 (−2.58, 1.68)		−0.03 (−0.59, 0.52)		0.13 (−0.62, 0.88)		−0.17 (−1.21, 0.87)		0.38 (−0.24, 1.01)		0.41 (−0.43, 1.26)		0.05 (−0.57, 0.68)
Non-whitea
Stage		0.37		0.70		0.83		0.27		0.47		0.09		0.20		0.69
III/IV	0.2 (−0.23, 0.62)		0.32 (−1.68, 2.31)		0.04 (−0.35, 0.43)		0.29 (−0.22, 0.81)		0.28 (−0.49, 1.04)		0.37 (−0.06, 0.81)		0.36 (−0.21, 0.93)		−0.09 (−0.53, 0.35)
I/IIa
Tumour locat		0.77		0.84		0.99		0.58		0.28		0.87		0.59		0.45
Colon	−0.06 (−0.48, 0.36)		0.14 (−1.54, 1.81)		0 (−0.38, 0.37)		−0.14 (−0.65, 0.36)		0.4 (−0.32, 1.12)		0.04 (−0.39, 0.46)		0.15 (−0.43, 0.72)		−0.16 (−0.59, 0.26)
Rectuma
Timepoint		0.10		0.61		0.16		0.27		0.74		0.00		0.39		0.49
Baselinea
6 Mo	−0.14 (−0.39, 0.1)		−0.07 (−1.09, 0.96)		0.01 (−0.29, 0.31)		−0.13 (−0.41, 0.14)		0.08 (−0.33, 0.49)		0.03 (−0.22, 0.27)		0.28 (−0.16, 0.73)		−0.02 (−0.36, 0.32)
12 Mo	−0.28 (−0.54, −0.02)		−0.49 (−1.5, 0.51)		0.15 (−0.17, 0.47)		0.04 (−0.25, 0.33)		0.24 (−0.19, 0.66)		0.12 (−0.13, 0.37)		0.28 (−0.14, 0.7)		0.23 (−0.13, 0.59)
24 Mo	0.12 (−0.28, 0.51)		−0.31 (−1.8, 1.18)		0.51 (0.05, 0.97)		0.33 (−0.12, 0.79)		0.08 (−0.49, 0.65)		0.37 (−0.01, 0.74)		−0.02 (−0.65, 0.61)		0.23 (−0.29, 0.75)

Abbreviations: CI=confidence interval; P-val=P-value; locat=location; Mo=month. † miR203 analysis not done due to small sample size; miRNA measured in ln (normalised copies).

^aReference.