Table 1. Demographic and tumour characteristics of prostate cancer patients at baseline by ADT exposure.
| ADT not used (N=5467) | ADT used (N=2170) | Total (N=7637) | P-value | |
|---|---|---|---|---|
|
Age, years | ||||
| ⩽65 | 2072 (37.9) | 430 (19.8) | 2502 (32.8) | <0.0001 |
| >65 | 3395 (62.1) | 1740 (80.2) | 5135 (67.2) | |
|
Charlson score 1 year before PC diagnoses | ||||
| 0 | 2716 (60.3) | 826 (52.7) | 3542 (58.4) | <0.0001 |
| 1–2 | 1426 (31.7) | 584 (37.3) | 2010 (33.1) | |
| 3+ | 361 (8.0) | 157 (10.0) | 518 (8.5) | |
| Missing | 964 | 603 | 1567 | |
|
Race/ethnicity | ||||
| Hispanic | 793 (14.5) | 312 (14.4) | 1105 (14.5) | 0.0097 |
| White | 3356 (61.4) | 1292 (59.5) | 4648 (60.9) | |
| African-American | 856 (15.7) | 405 (18.7) | 1261 (16.5) | |
| Asian | 462 (8.5) | 161 (7.4) | 623 (8.2) | |
|
Hypertension | ||||
| No | 2237 (40.9) | 789 (36.4) | 3026 (39.6) | 0.0002 |
| Yes | 3230 (59.1) | 1381 (63.6) | 4611 (60.4) | |
|
Diabetes | ||||
| No | 4572 (83.6) | 1729 (79.7) | 6301 (82.5) | <0.0001 |
| Yes | 895 (16.4) | 441 (20.3) | 1336 (17.5) | |
|
Year of PC diagnosis | ||||
| 1998–2000 | 1256 (23.0) | 826 (38.1) | 2082 (27.3) | <0.0001 |
| 2001–2005 | 2465 (45.1) | 899 (41.4) | 3364 (44.0) | |
| 2006+ | 1746 (31.9) | 445 (20.5) | 2191 (28.7) | |
|
Stage at diagnosis | ||||
| T1 | 3726 (69.1) | 1196 (55.8) | 4922 (65.3) | <0.0001 |
| T2 | 1600 (29.7) | 837 (39.0) | 2437 (32.3) | |
| T3 | 69 (1.3) | 112 (5.2) | 181 (2.4) | |
| Missing | 72 | 25 | 97 | |
|
Gleason score | ||||
| <7 | 3388 (69.0) | 851 (42.3) | 4239 (61.2) | <0.0001 |
| 7 | 1088 (22.1) | 631 (31.4) | 1719 (24.8) | |
| >7 | 437 (8.9) | 528 (26.3) | 965 (13.9) | |
| Missing | 554 | 160 | 714 | |
|
Risk groups | ||||
| Low | 2218 (47.7) | 389 (19.2) | 2607 (39.1) | <0.0001 |
| Intermediate | 1398 (30.1) | 637 (31.5) | 2035 (30.5) | |
| High | 1030 (22.2) | 997 (49.3) | 2027 (30.4) | |
| Missing | 821 | 147 | 968 | |
|
Preexisting CVD | ||||
| No | 4290 (78.5) | 1682 (77.5) | 5972 (78.2) | 0.3598 |
| Yes | 1177 (21.5) | 488 (22.5) | 1665 (21.8) | |
|
Smoking statusa | ||||
| Current | 451 (12.8) | 190 (12.9) | 641 (12.8) | 0.0078 |
| Former | 1472 (41.7) | 680 (46.1) | 2152 (43.0) | |
| Never | 1611 (45.6) | 605 (41.0) | 2216 (44.2) | |
| Missing | 1933 | 695 | 2628 | |
|
BMIb | ||||
| Underweight or normal | 498 (30.0) | 172 (38.0) | 670 (31.7) | 0.0098 |
| Overweight | 729 (43.9) | 181 (40.0) | 910 (43.0) | |
| Obese | 435 (26.2) | 100 (22.1) | 535 (25.3) | |
Abbreviations: ADT=androgen deprivation therapy; BMI=body mass index; CVD=cardiovascular disease; PC=prostate cancer.
P-value based on Pearson’s chi-square test, two-sided.
a
35% was missing, smoking history was not available in EMR until 2004.
b
72% missing, BMI was not available in EMR until 2006.