Table 3. Crude disease rates and hazard ratios of incident CVD outcomes.
|
Total, PY: 31 255 |
ADT used, PY: 7527 |
ADT not used, PY: 23 728 |
All patients (n=7637) |
Patients without preexisting CVD (n=5972) |
Patients with preexisting CVD (n=1665) |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CVD | N | Crude ratea | N | Crude rate | N | Crude rate | Adjusted HR | 95% CI | Adjusted HR | 95% CI | Adjusted HR | 95% CI |
|
Cardiac ischaemia | ||||||||||||
| AMI | 431 | 13.79 | 139 | 18.47 | 292 | 12.31 | 1.19 | 0.95, 1.49 | 1.24 | 0.93, 1.64 | 1.14 | 0.78, 1.65 |
| Angina | 61 | 1.95 | 18 | 2.39 | 43 | 1.81 | 0.95 | 0.52, 1.75 | 0.64 | 0.24, 1.67 | 1.31 | 0.58, 2.93 |
| Cardiac arrest | 58 | 1.86 | 19 | 2.52 | 39 | 1.64 | 1.15 | 0.62, 2.12 | 1.29 | 0.61, 2.76 | 0.85 | 0.25, 2.83 |
| Total | 550 | 17.68 | 176 | 23.38 | 374 | 15.76 | 1.15 | 0.95, 1.41 | 1.18 | 0.91, 1.52 | 1.13 | 0.82, 1.57 |
|
Stroke | ||||||||||||
| Total | 71 | 2.27 | 23 | 3.06 | 48 | 2.02 | 1.09 | 0.63, 1.88 | 0.93 | 0.46, 1.88 | 1.62 | 0.64, 4.12 |
|
Other heart diseases | ||||||||||||
| Arrhythmia | 564 | 18.05 | 176 | 23.38 | 388 | 16.35 | 1.17 | 0.96, 1.43 | 1.07 | 0.84, 1.37 | 1.44 | 1.02, 2.01 |
| Heart failure | 689 | 22.04 | 244 | 32.42 | 445 | 18.75 | 1.27 | 1.06, 1.51 | 1.81 | 1.40, 2.32 | 1.00 | 0.78, 1.29 |
| Cardmyopathy | 36 | 1.15 | 16 | 2.13 | 20 | 0.84 | 1.84 | 0.87, 3.88 | 2.25 | 0.74, 6.78 | 1.51 | 0.51, 4.46 |
| Conduction disorder | 81 | 2.59 | 27 | 3.59 | 54 | 2.28 | 1.40 | 0.84, 2.35 | 1.08 | 0.57, 2.03 | 3.11 | 1.22, 7.91 |
| Hypertensive heart disease | 3 | 0.1 | 1 | 0.13 | 2 | 0.08 | NA | NA | NA | NA | NA | NA |
| Valvuopathy | 67 | 2.14 | 22 | 2.92 | 45 | 1.90 | 1.22 | 0.69, 2.17 | 1.08 | 0.53, 2.21 | 1.59 | 0.59, 4.26 |
| Total | 1440 | 45.64 | 486 | 64.56 | 954 | 40.21 | 1.25 | 1.11, 1.42 | 1.34 | 1.14, 1.58 | 1.22 | 1.01, 1.47 |
Abbreviations: ADT=androgen deprivation therapy; AMI=acute myocardial infarction; CI=confidence interval; CVD=cardiovascular disease; HR=hazard ratio; NA=not applicable; PY=person-years.
HRs adjusted for: ADT (time dependent), hypertension (Y/N), diabetes (Y/N), Gleason scores (<7/7/>7), stage at diagnosis (T1/T2/T3), grading for PC (1/2/3/4), year of PC diagnosis (<2000/2001–2005/⩾2006), race (White/African/Asian/Hispanic), age (>65/⩽ 65 years), calcium channel blockers (time dependent), anticoagulants (time dependent), antilipemics (time dependent), digoxin (time dependent), nitrates (time dependent), antidiabetic drugs (time dependent), baseline PSA level (⩽ 4/4–10/10–20/>20), risk group (low/intermediate/high), and Charlson score 1 year before diagnose (0/1–2/⩾3). Bold values: 95% confidence intervals do not include 1.00.
Crude rate: rate per 1000 person-years.