Table 2. Circulating resistin levels and risk of MM, overall and stratified by selected characteristics.
|
Quartile (Q) |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
Q1 |
Q2 |
Q3 |
Q4 |
|||||||
| Ncases | OR (95% CI) | Ncases | OR (95% CI) | Ncases | OR (95% CI) | Ncases | OR (95% CI) | Ptrend | Pinta | |
| Crude | 55 | 1.0 (ref) | 48 | 0.87 (0.53–1.44) | 33 | 0.61 (0.36–1.03) | 42 | 0.75 (0.45–1.25) | 0.20 | |
| Adjusted for BMI | 54 | 1.0 (ref) | 48 | 0.87 (0.52–1.46) | 32 | 0.60 (0.35–1.02) | 41 | 0.76 (0.45–1.29) | 0.24 | |
| Adjusted for BMI and adiponectin | 54 | 1.0 (ref) | 48 | 0.86 (0.51–1.43) | 32 | 0.59 (0.35–1.01) | 41 | 0.76 (0.45–1.29) | 0.24 | |
| By sex | ||||||||||
| Female | 9 | 1.0 (ref) | 11 | 1.27 (0.44–3.64) | 12 | 1.56 (0.55–4.45) | 17 | 1.82 (0.66–5.00) | 0.23 | |
| Male | 46 | 1.0 (ref) | 37 | 0.77 (0.43–1.38) | 21 | 0.44 (0.24–0.83) | 25 | 0.54 (0.29–0.995) | 0.03 | 0.12 |
| By time to MM diagnosis | ||||||||||
| <7 years | 28 | 1.0 (ref) | 20 | 0.63 (0.29–1.37) | 14 | 0.41 (0.18–0.90) | 23 | 0.61 (0.30–1.25) | 0.21 | |
| ⩾7 years | 27 | 1.0 (ref) | 28 | 1.14 (0.58–2.26) | 19 | 0.92 (0.45–1.87) | 19 | 0.87 (0.41–1.86) | 0.61 | 0.47 |
| By BMI_categoryb | ||||||||||
| <25 kg m−2 | 23 | 1.0 (ref) | 12 | 0.59 (0.25–1.36) | 13 | 0.68(0.29–1.57) | 13 | 0.61 (0.27–1.40) | 0.30 | |
| 25–29.9 kg m−2 | 19 | 1.0 (ref) | 26 | 0.98 (0.44–2.18) | 17 | 0.60 (0.26–1.42) | 16 | 0.62 (0.26–1.52) | 0.20 | |
| ⩾30 kg m−2 | 12 | 1.0 (ref) | 10 | 1.31 (0.43–3.95) | 2 | 0.23 (0.04–1.21) | 12 | 1.47 (0.46–4.64) | 0.91 | 0.45 |
| By age at blood draw | ||||||||||
| <65 years | 34 | 1.0 (ref) | 31 | 0.86 (0.45–1.64) | 17 | 0.55 (0.27–1.13) | 18 | 0.61 (0.29–1.26) | 0.12 | |
| ⩾65 years | 21 | 1.0 (ref) | 17 | 0.87 (0.38–1.97) | 16 | 0.64 (0.29–1.41) | 24 | 0.89 (0.42–1.91) | 0.78 | 0.76 |
Abbreviations: BMI=body mass index; CI=confidence interval; MM=multiple myeloma; OR=odds ratio; Pint=Pinteraction; ref=reference.
Odds ratios and 95% CI were estimated using conditional logistic regression models, unless otherwise noted. Quartile cut-off points were defined on the basis of the distribution of cohort- and sex-adjusted resistin levels among controls, as follows: Q1⩽4.59 ng ml−1, Q2 4.60–5.82 ng ml−1, Q3 5.83–7.37 ng ml−1, and Q4⩾7.38 ng ml−1.
a
Tests of multiplicative interaction were based on the same models as those used for the stratified analyses and were performed using Wald tests.
b
Unconditional logistic regression adjusted for cohort, age, sex and fasting status.