Table 3.
Test-retest intraclass correlation coefficients (ICCs), Bland-Altman limits of agreements (BA-Las), Bias and coefficients of variation (CVs) of intravoxel incoherent motion (IVIM)–diffusion-weighted imaging (DWI) values for each anatomical region
| ROI 1 | ROI 2 | ROI 3 | ROI 4 | ROI 5 | ROI 6 | ROI 7 | Mean of all ROI | ||
|---|---|---|---|---|---|---|---|---|---|
| ICC (mean) [95% CI] |
ADC | 0.96 [0.91–0.98] |
0.95 [0.87–0.98] |
0.94 [0.85–0.97] |
0.54 [0–0.81] |
0.75 [0.39–0.90] |
0.89 [0.70–0.96] |
0.77 [0.45–0.91] |
0.87 [0.82–0.90] |
| D | 0.94 [0.86–0.98] |
0.93 [0.83–0.97] |
0.86 [0.67–0.94] |
0.72 [0.35–0.88] |
0.71 [0.28–0.88] |
0.94 [0.85–0.97] |
0.59 [0; 0.83] |
0.90 [0.87–0.93] |
|
| PF | 0.91 [0.78–0.96] |
0.90 [0.77–0.96] |
0.91 [0.79–0.96] |
0.75 [0.40–0.90] |
0.76 [0.41–0.90] |
0.86 [0.64–0.94] |
0.90 [0.77–0.96] |
0.87 [0.83–0.91] |
|
| D* | 0.84 [0.62–0.93] |
0.65 [0.15–0.86] |
0.75 [0.41–0.90] |
0.35 [0; 0.73] |
0.32 [0–0.72] |
0.76 [0.43–0.90] |
0.78 [0.46–0.91] |
0.73 [0.63–0.80] |
|
| BA-LA | ADC | [-0.29–0.26] | [-0.35–0.35] | [-0.61–0.75] | [-1.48–1.60] | [-0.52–0.55] | [-0.44–0.26] | [-0.13–0.13] | [-0.69–0.70] |
| D | [-0.28–0.25] | [-0.36–0.27] | [-0.36–0.45] | [-0.48–0.35] | [-0.45–0.45] | [-0.12–0.13] | [-0.10–0.11] | [-0.33–0.31] | |
| PF | [-0.08–0.08] | [-0.10–0.10] | [-0.09–0.10] | [-0.15–0.17] | [-0.12–0.13] | [-0.12–0.08] | [-0.06–0.07] | [-15.9–14.7] | |
| D* | [-11.8–13.2] | [-23.1–20.9] | [-17.6–12.0] | [-14.7–17.7] | [-15.6–16.3] | [-12.3–8.0] | [-13.2–11.9] | [-0.10–0.11] | |
| Bias (mean) [95% CI] |
ADC | -0.01 [-0.08–0.05] |
0.00 [-0.08–0.08] |
0.07 [-0.09–0.22] |
0.06 [-0.28–0.41] |
0.01 [-0.11–0.14] |
-0.09 [-0.17–-0.01] |
0 [-0.03–0.03] |
0.01 [-0.05–0.06] |
| D | -0.02 [-0.08–0.04] |
-0.04 [-0.11–0.03] |
0.05 [-0.04–0.14] |
-0.06 [-0.16–0.03] |
0 [-0.10–0.10] |
0 [-0.03–0.03] |
0 [-0.02–0.03] |
-0.01 [-0.04–0.02] |
|
| PF | 0 [-0.02–0.02] |
0.00 [-0.02–0.03] |
0.00 [-0.02–0.03] |
0.01 [-0.02–0.05] |
0.01 [-0.02–0.03] |
-0.02 [-0.04–0.00] |
0.01 [-0.01–0.02] |
0 [-0.01–0.01] |
|
| D* | 0.71 [-2.13–3.54] |
-1.1 [-6.08–3.89] |
-2.78 [-6.14–0.57] |
1.50 [-2.17–5.16] |
0.35 [-3.26–3.96] |
-2.15 [-4.45–0.15] |
-0.64 [-3.48–2.19] |
-0.59 [-1.83–0.65] |
|
| CV (mean) (SD) | ADC | 0.21 (0.06) | 0.12 (0.05) | 0.18 (0.06) | 0.22 (0.06) | 0.22 (0.07) | 0.33 (0.13) | 0.23 (0.06) | 0.22 (0.09) |
| D | 0.23 (0.06) | 0.14 (0.05) | 0.19 (0.06) | 0.25 (0.07) | 0.25 (0.06) | 0.29 (0.06) | 0.22 (0.05) | 0.22 (0.07) | |
| PF | 0.62 (0.18) | 0.43 (0.17) | 0.51 (0.15) | 0.51 (0.13) | 0.54 (0.1) | 0.66 (0.11) | 0.75 (0.14) | 0.57 (0.17) | |
| D* | 1.5 (0.4) | 1.1 (0.4) | 1.3 (0.4) | 1.3 (0.4) | 1.3 (0.4) | 1.6 (0.2) | 1.2 (0.2) | 1.3 (0.4) | |
CI confidence interval, ADC apparent diffusion coefficient, D ‘true’ diffusion coefficient, D* pseudodiffusion coefficient, f perfusion fraction, ROI region of interest