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Illustration of 3′-tsRNAs in suppressing LTR-retrotransposon (ERV), and the potential functions of 5′-tsRNAs. Right panel: 3′-tsRNAs with 18 nt in length block ERV reverse transcription by competing with intact tRNAs for PBS; 3′-tsRNAs with 22 nt in length exert post-transcriptional silencing of retroviral protein production by targeting its mRNA. Left panel: cell-specific distribution and potential functions of 5′-tsRNAs.
