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. 2017 Aug 25;27(11):1341–1350. doi: 10.1038/cr.2017.110

Figure 1.

Figure 1

Overall structure of the DNA-PK complex. (A) Color-coded domain architecture of human DNA-PKcs, KU70 and KU80. The same color scheme is used in all of the structure figures if not otherwise specified. The secondary structure of the biotinylated DNA is shown with the free and blocked DNA ends as indicated. The bases that were not built into the structural model are colored in gray. The inter- and intra-molecular contacts are shown as connected lines. Three major contacts (Interface-1 to Interface-3) between DNA-PKcs and KU70/80 are indicated. (B-D) Ribbon representations of the DNA-PK complex in three different views. The CoreDNA-PKcs (composed of the FAT, KD and FATC) is indicated with dashed rectangle. The DNA is colored in yellow. The bases of DNA are shown in stick representations. FAT, FRAP, ATM, TRRAP domain; FATC, FAT C-terminal domain; KD, kinase domain; M-HEAT, middle HEAT repeats; N-HEAT, N-terminal HEAT repeats.