TABLE 1.
Top seven candidates (together with known antigen Hcp1) identified via bioinformatics and immunoinformatics analyses
| Protein | Locus |
Placement |
Seroreactivity | Expression | ||
|---|---|---|---|---|---|---|
| B. mallei | B. pseudomallei | MHC-I | MHC-II | |||
| Hemagglutinin | BMAA1324 | BPSS0908 | 1 | 20 | Yes | Yes (22, 23) |
| FlgD | BMA3327 | BPSL0272 | 4 | —a | Unknown | Unknown |
| OmpW | BMA2010 | BPSL2704 | 5 | 7 | Unknown | In vitrob (21) |
| FlgL | BMA3336 | BPSL0281 | 8 | 21 | Unknown | Unknown |
| Porin OpcP1 | BMAA1122 | BPSS0708 | 9 | 3 | Yes | Yes (22) |
| Porin | BMAA0599 | BPSS0757 | 12 | 4 | Unknown | Unknown |
| Porin OpcP | BMAA1353 | BPSS0879 | — | 1 | Yes | In vitroc (21, 25) |
| Hcp1 | BMAA0742 | BPSS1498 | 13 | — | Yes | Yes (14) |
a
—, not available.
b
For 5.9% of B. pseudomallei OMPs.
c
For 4.6% of B. pseudomallei OMPs and 2.5% of B. mallei OMPs.