FIG 3.

Cytokine production in the lungs and spleens from M. tuberculosis Beijing/K-infected mice following ex vivo stimulation with MTBK_24820. Concentrations of protection-related cytokines to MTBK_24820 (5 μg/ml) were determined ex vivo at 4 and 9 weeks postinfection. Concentrations of IL-2 (A), IL-6 (B), IFN-γ (C), and IL-17 (D) in cell culture supernatants were measured. Data are presented as means ± SD from five mice. Significant differences between multiple groups were analyzed by unpaired t tests (**, P < 0.01).