Table 2. . CpGs with differential methylation (p < 1.0 × 10-5) in relation to lung function in a Korean chronic obstructive pulmonary disease cohort, ordered by chromosomal location.
| Chr† | Gene (distance to gene‡) | Trait | Probe | Position§ | Coef¶ | SE# | p-value†† |
|---|---|---|---|---|---|---|---|
| 1 | LDLRAD1 | Ratio | cg09175620 | 54484536 | -1.6 | 0.3 | 3.4 × 10-6 |
| AK5 | FVC‡‡ | cg05347985 | 77751443 | -14.0 | 3.0 | 8.9 × 10-6 | |
| TTC24 | Ratio | cg03760759 | 156549533 | -1.7 | 0.4 | 8.2 × 10-6 | |
| DUSP5P | FEV1§§ | cg10107958¶¶,## | 228783383 | -13.3 | 2.8 | 8.4 × 10-6 | |
| 3 | CCDC13 | Ratio | cg02828993¶¶ | 42775696 | -2.8 | 0.6 | 8.2 × 10-6 |
| SRPRB (40) | FEV1 | cg20276088 | 133502917 | 9.7 | 2.1 | 8.7 × 10-6 | |
| 7 | SNX10 | Ratio | cg06280210##,††† | 26331247 | -7.1 | 1.5 | 7.7 × 10-6 |
| 8 | CSMD3 | Ratio | cg20564273 | 114446439 | -5.0 | 1.0 | 7.3 × 10-6 |
| 9 | NXNL2 (43179) | Ratio | cg14210862¶¶,## | 91193195 | -3.5 | 0.7 | 7.8 × 10-6 |
| 10 | DIP2C | Ratio | cg03559389 | 679322 | -6.9 | 1.2 | 8.1 × 10-8 |
| SMNDC1 | Ratio | cg26944434## | 112064524 | -7.3 | 1.5 | 5.1 × 10-6 | |
| 11 | FAR1 | Ratio | cg24412501## | 13690194 | -6.1 | 1.3 | 9.8 × 10-6 |
| PATL1 (35101) | Ratio | cg06022671 | 59439293 | -2.6 | 0.5 | 3.7 × 10-6 | |
| 12 | NT5DC3 | FEV1 | cg15977278## | 104234975 | -31.1 | 6.6 | 9.6 × 10-6 |
| 14 | SERPINA12 | FVC | cg19904425 | 94984530 | -3.7 | 0.8 | 7.1 × 10-6 |
| 19 | C19orf18 | FEV1 | cg09440215 | 58480646 | -19.8 | 4.2 | 7.7 × 10-6 |
†Chromosome.
‡Distance to transcription start site of the mapped gene (basepair, bp).
§Physical position (bp, National Center for Biotechnology Information human reference genome assembly Build 37.3).
¶Regression coefficient from statistical models. Covariates age, sex, height, smoking status, pack-years and estimated cell-type proportions were included in the models for FEV1, FEV1/FVC and COPD. Additionally, weight was included in the model for FVC. FEV1 and FVC were in liters and methylation (β) was ranged between 0 and 1 in the analyses.
#Standard error of regression coefficient.
††Uncorrected p-value.
‡‡Forced vital capacity.
§§Forced expiratory volume in 1 s.
¶¶Enhancer.
##Promoter associated.
†††DNaseI hypersensitivity site.
COPD: Chronic obstructive pulmonary disease; FEV1: Forced expiratory volume in 1 second; FVC: Forced vital capacity.