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IHC studies (10×) of G2 NFP-NET. (A) Nuclear loss of expression for MLH1 protein; (B) nuclear loss of expression for PMS2 protein; (C) MSH2 protein nuclear expression; (D) MSH6 protein nuclear expression. Neoplastic cells display a trabecular pattern. Tumor cell nuclei show loss of MLH1 and PMS2 expression (A,B) and maintain MSH2 and MSH6 expression (C,D). IHC, immunohistochemistry.
