Table 2.
Daily values and peak day of biomarkers and Sequential Organ Failure Assessment (SOFA) score in critically ill patients with organ dysfunction
| Biomarkers or SOFA score | Level/point or peak day | Patients with maximum value, n (%) |
|---|---|---|
| IL‐6 | ||
| Serum level, pg/mL | ||
| Day 1 | 953 (157–9,451) | 52 (56.5) |
| Day 2 | 508 (175–3,252) | 22 (23.9) |
| Day 3 | 158 (87–536) | 7 (7.6) |
| Day 4 | 112 (51–358) | 8 (8.7) |
| Day 5 | 99 (40–182) | 3 (3.3) |
| Maximum | 2,241 (481–20,903) | |
| Peak day | 1 (1–2) | |
| PCT | ||
| Serum level, ng/mL | ||
| Day 1 | 5.50 (0.37–52.90) | 36 (39.1) |
| Day 2 | 9.28 (1.86–38.02) | 35 (38.0) |
| Day 3 | 6.63 (2.38–33.85) | 16 (17.4) |
| Day 4 | 3.90 (1.63–18.66) | 3 (3.3) |
| Day 5 | 2.41 (1.10–8.35) | 2 (2.2) |
| Maximum | 11.24 (3.51–60.92) | |
| Peak day | 2 (1–2) | |
| CRP | ||
| Serum level, mg/mL | ||
| Day 1 | 11.7 (2.2–25.0) | 22 (23.9) |
| Day 2 | 16.4 (7.5–23.8) | 14 (15.2) |
| Day 3 | 18.6 (13.0–27.4) | 36 (39.1) |
| Day 4 | 16.0 (9.6–23.5) | 10 (10.9) |
| Day 5 | 11.2 (7.1–19.9) | 10 (10.9) |
| Maximum | 24.3 (16.1–29.3) | |
| Peak day | 3 (2–3) | |
| SOFA score | ||
| Day 1 | 10 (7–14) | 40 (43.5) |
| Day 2 | 10 (7–13) | 22 (23.9) |
| Day 3 | 9 (6–13) | 17 (18.5) |
| Day 4 | 9 (6–13) | 7 (7.6) |
| Day 5 | 8 (5–13) | 6 (6.5) |
| Maximum | 13 (8–16) | |
| Peak day | 2 (1–3) | |
Data are expressed as median (interquartile range) and number (percentage).
CRP, C‐reactive protein; IL‐6, interleukin‐6; Maximum, maximum value during initial 5 days; PCT, procalcitonin; Peak day, the day when SOFA score or biomarkers reached its maximum value.