Table 2.
Summary of the CD4 T cell responses to the Sp17 peptides by DLBCL patients.
Patients | MHC class II status | Sp17 protein | γ-IFN response to peptides per 50,000 cells | |||||
---|---|---|---|---|---|---|---|---|
Sp17(4) | Sp17(5) | Sp17(6) | No peptide | HIV-1 | PHA | |||
Significant response | ||||||||
1 | DRB1∗0102,∗1104 | + | 42 ± 4 | 16 ± 2 | 14 ± 4 | 12 ± 2 | 10 ± 4 | 92 ± 4 |
2 | DRB1∗0101,∗0701 | + | 28 ± 2 | 8 ± 2 | 18 ± 2 | 10 ± 2 | 6 ± 1 | 72 ± 12 |
5 | DRB1∗0301,∗0401 | − | 26 ± 4 | 12 ± 2 | 14 ± 2 | 8 ± 2 | 4 ± 0 | 108 ± 10 |
8 | DRB1∗1501,∗0803 | ND | 52 ± 4 | 12 ± 2 | 14 ± 4 | 10 ± 2 | 6 ± 2 | 78 ± 14 |
10 | DRB1∗0101 | ND | 36 ± 4 | 20 ± 2 | 10 ± 4 | 8 ± 2 | 4 ± 2 | 86 ± 6 |
12 | DRB1∗0401,∗1401 | + | 50 ± 2 | 22 ± 4 | 28 ± 4 | 16 ± 2 | 12 ± 4 | 128 ± 16 |
14 | DRB1∗1403,∗0401 | ND | 38 ± 4 | 14 ± 2 | 24 ± 6 | 8 ± 2 | 4 ± 2 | 78 ± 14 |
18 | DRB1∗0401,∗0401 | + | 32 ± 6 | 18 ± 2 | 16 ± 4 | 6 ± 2 | 10 ± 2 | 66 ± 12 |
No significant response | ||||||||
7 | DRB1∗0301,∗0701 | + | 18 ± 6 | 22 ± 2 | 26 ± 4 | 14 ± 2 | 12 ± 2 | 58 ± 8 |
9 | DRB1∗0301,∗1601 | − | 16 ± 8 | 32 ± 4 | 20 ± 4 | 18 ± 2 | 14 ± 4 | 108 ± 10 |
15 | DRB1∗1301,∗1101 | ND | 10 ± 2 | 12 ± 2 | 20 ± 4 | 10 ± 2 | 14 ± 2 | 58 ± 8 |
19 | DRB1∗0401,∗0901 | + | 14 ± 2 | 18 ± 2 | 6 ± 1 | 12 ± 2 | 8 ± 2 | 50 ± 8 |
20 | DRB1∗1104,∗1501 | + | 24 ± 4 | 26 ± 2 | 14 ± 4 | 14 ± 2 | 12 ± 2 | 72 ± 10 |
21 | DRB1∗0301,∗1303 | + | 10 ± 2 | 14 ± 2 | 18 ± 2 | 9 ± 2 | 8 ± 2 | 86 ± 6 |
39 | DRB1∗0701 | − | 32 ± 4 | 26 ± 2 | 14 ± 2 | 16 ± 2 | 14 ± 2 | 112 ± 16 |
43 | DRB1∗0101,∗1101 | − | 24 ± 4 | 32 ± 2 | 28 ± 2 | 18 ± 4 | 20 ± 2 | 98 ± 12 |
48 | DRB1∗0101,∗0405 | − | 28 ± 4 | 10 ± 2 | 18 ± 2 | 18 ± 4 | 14 ± 2 | 98 ± 8 |
DLBCL(dn): de novo diffuse large B cell lymphoma; DLBCL(t): diffuse large B cell lymphoma transformed; TCR: T cell rich B cell lymphoma. The results +/− are from triplicate ELISPOT cultures. The SD was calculated using standard techniques. Significant γ-IFN responses are highlighted in bold. ND, not determined.