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Anxiety-like behavior was measured by elevated plus maze test. (a) The percentage of the time spent in the open arms. (b) The percentage of the distance traveled in the open arms. (c) The number of entries into open arms. (d) The number of entries into open arms/number of entries to the open plus closed arms. The data were presented as mean ± SEM. ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001 versus WT mice. n = 10–15 for each group.
