Validation of differentially expressed proteins of CPLX2, SNP25, and SYN2 by Western blot analysis. (a and b) The relative levels of CPLX2 in the hippocampus in WT mice, nontreated 3xTg-AD mice, and Rg1-treated 3xTg-AD mice. (a and c) The relative levels of SNP25 in the hippocampus in WT mice, nontreated 3xTg-AD mice, and Rg1-treated 3xTg-AD mice. (a and d) The relative levels of SYN2 in the hippocampus in WT mice, nontreated 3xTg-AD mice, and Rg1-treated 3xTg-AD mice. (a and e) The relative levels of PSD-95 in the hippocampus in WT mice, nontreated 3xTg-AD mice, and Rg1-treated 3xTg-AD mice. The data were presented as mean ± SEM. ∗p < 0.05 and ∗∗p < 0.01 versus WT; #p < 0.05 and ##p < 0.01 versus 3Tg. n = 3 for each group.