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. 2017 Nov 7;5:17034. doi: 10.1038/boneres.2017.34

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Macroscopic and micro-CT images of tibial plateaus from non-diabetic and diabetes patients. Macroscopic images were shown in (a–c). Black arrows (b,c) indicated edges of the remained cartilage in OA specimens. The corresponding micro-CT images were displayed in (d–f) (top view) and (g–i) (coronal view), with the red rectangles indicating the ROIs of subchondral bone (solid lines) and subchondral plate (dashed lines) on medial and lateral sides. White arrows (b,c,e,f,h,i) indicate osteophytes in non-diabetic and diabetes groups.