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. 2017 Nov 7;5:17034. doi: 10.1038/boneres.2017.34

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Copyright © 2017 The Author(s)

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Activity of TRAP⁺ osteoclasts in subchondral bone from non-diabetic and diabetes patients. (a) Diabetes group generated larger bone marrow cavities than non-diabetic group on both lateral and medial sides. (b) One-way ANOVA analysis showed that there were significant differences in TRAP⁺ osteoclasts among groups on both sides. Of note, the number of TRAP⁺ osteoclasts in diabetes group was higher than non-diabetic group. In addition, the numbers of TRAP⁺ osteoclasts on medial sides were higher than lateral sides in both non-diabetic and diabetes group. Insert: morphology of TRAP⁺ osteoclasts. ^#P<0.05 vs non-diabetic group and *P<0.05 vs control group on the same side according to Post-hoc tests; ^{^}P<0.05 between lateral and medial sides in non-diabetic group; ^&P<0.05 between lateral and medial sides in diabetic group.