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. 2017 Nov 6;11:25. doi: 10.1186/s40246-017-0123-5

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Identification of a dystonia-associated locus on chromosome 17. a Pedigree of an extended family with novel syndromic familial tremulous dystonia. b Genome-wide linkage analysis revealed a maximal peak with a LOD score of 4.58 on chromosome 17. c AutoSNPa output for chromosome 17 reveals an ROH (boxed in red) shared among affected members (IV:1, IV:2, IV:3, IV:7, and IV:8) and not present in unaffected individuals (IV:4, IV:5, IV:6, and IV:9)