Table 3.

Comparison of qualitative tests of MET-PET for differentiation between LR and RN in BM

First author & year	No. of lesions	LNR cut-off value	Sensitivity (%)	Specificity (%)	AUC
Tsuyuguchi, 2005	21	1.42a	78	100	NR
Terakawa, 2008	51	1.41a	79	75	0.78
Minamimoto, 2015	42	1.30b	82	86	0.89
Present study, 2017	37	1.40b	82	75	0.84

MET-PET ¹¹C–methionine positron emission tomography, LR local recurrence, RN radiation necrosis, BM brain metastases, LNR lesion/normal ratios, AUC area under the curve, NR not reported

^aSUV_mean (lesion)/SUV_mean (reference), ^bSUV_max (lesion)/SUV_max (reference)