Table 6.

Distrubition by age of allele and genotype frequencies of the rs1050504 and rs2228505 polymorphisms between pulmonary tuberculosis patients and healthy controls

	≤ 29 years				30–49 years				≥ 50 years
	PTB (%)	Controls (%)	p-Value	OR (95% CI)	PTB (%)	Controls (%)	p-Value	OR (95% CI)	PTB (%)	Controls (%)	p-Value	OR (95%CI)
rs1050504[C/T]
Genotypes	n = 60	n = 44			n = 49	n = 81			n = 13	n = 16
CC	31(51,7)	29 (65,9)	0,14	0,55(0,24–1,27)	28 (57,1)	43 (53,1)	0,65	1,17 (0,57–2,4)	8 (61,5)	9 (56,2)	0,91	1,08 (2,23–4,94)
CT	27 (45)	12 (27,3)	0,06	2,18 (0,94–5,03)	18 (36,8)	20 (24,7)	0,14	1,77 (0,82–3,82)	5 (38,5)	6 (37,5)	0,82	1,19 (0,25–5,49)
TT	2 (3,3)	3 (6,8)	0,41	0,47 (0,07–2,94)	3 (6,1)	18 (22,2)	0,01*	0,22 (0,06–0,82)	0	1 (6,3)	0,37	ND
Alleles
C	89 (74,2)	70 (79,5)	0,36	0,73 (0,38–1,42)	74 (75,5)	106 (65,4)	0,08	1,62 (0,92–2,85)	19 (79,2)	24 (75)	0,71	1,26 (0,35–4,5)
T	31 (25,8)	18 (20,5)			24 (24,5)	56 (34,6)			5 (20,8)	8 (25)
rs2228505[T/C]
Genotypes	n = 64	n = 40			n = 52	n = 62			n = 12	n = 15
TT	47 (73,5)	31 (77,5)	0,64	0,80 (0,31–2,02)	38 (73,1)	52 (83,9)	0,15	0,52 (0,20–1,30)	10 (83,3)	12 (80)	0,82	1,25 (0,17–9,01)
CT	15 (23,4)	9 (22,5)	0,91	1,05 (0,41–2,7)	13 (25)	10 (16,1)	0,23	1,73 (0,68–4,36)	2 (16,7)	3 (20)	0,82	0,8 (0,11–5,77)
CC	2 (3,1)	0	0,25	ND	1 (1,9)	0	0,27	ND	0	0	ND	ND
Alleles
T	109 (85,2)	71 (88,7)	0,46	0,72 (0,31–1,69)	89 (85,6)	114 (92)	0,12	0,52 (0,22–1,21)	22 (91,7)	27 (90)	0,83	1,22 (0,18–7,97)
C	19 (14,8)	9 (11,3)			15 (14,4)	10 (8)			2 (8,3)	3 (10)

*Significant p-values appear in bold