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. 2017 Nov 6;18:468. doi: 10.1186/s12859-017-1882-7

Fig. 4.

Fig. 4

Illustration of local update. Two kinds of rewriting rules are applied to narrow the gap between predicted and target structures. Red bases {A U 3,11} and {A U 4,10} are updated to form base pairs, while blue bases {G C 2,13} are updated so that the pair is destroyed. Positions 5, 7 and 9 are essential positions and not updated. a Nucleotides need to be updated. b Updated RNA sequence