Table 2.

Risk factors for development of peripheral neuropathy.

Study	Year	Study Type	No. with peripheral neuropathy (%)	Diagnostic criteria	Findings
Henderson et al.	1971	Prospective	36 of 249 (15%)	EMG/NCS	Polyneuropathy was more common in burns over 20% TBSA.
Marquez et al.	1993	Retrospective	19 of 800 (2%)	Clinical assessment followed by EMG/NCS	Most patients with peripheral neuropathy had multiple nerves affected (three or more).
					Of the patients that presented with peripheral neuropathy, 69% were severely burned with TBSA greater than 20%. The number of nerves affected correlated with the full thickness burn area.
Khedr et al.	1997	Prospective	16 of 55 (29%)	EMG/NCS followed by clinical assessment	Mononeuropathy multiplex was diagnosed in 56% of patients. Generalized peripheral neuropathy was noted in 31% of patients.
					Higher prevalence of neuropathy associated with age > 20, burns involving full thickness wounds, and TBSA > 20%.
Kowlske et al.	2001	Retrospective	64 of 572 (11%)	Clinical assessment	Of the patients that presented with peripheral neuropathy, 56 patients (88%) had mononeuropathy, while 18 patients (28%) had polyneuropathy. Of these patients, 10 (16%) had both mononeuropathy and polyneuropathy.
					Higher prevalence of neuropathy associated with severe burn injury in patients who were older (>40 years), critically ill, had an electrical injury, or a history of alcohol abuse.
Lee et al.	2009	Retrospective	35 of 868 (4%)	Clinical assessment followed by EMG/NCS	Flame injuries and full thickness burn injuries were most common in patients with peripheral neuropathy.
Tamam et al.	2013	Retrospective	47 of 648 (7%)	Clinical assessment followed by EMG/NCS	Of the patients with peripheral neuropathy, 68% of patients had mononeuropathy while 42% had polyneuropathy.
					Most frequent etiology of mononeuropathy was low-voltage electrical injury (<1000V) (50%).

EMG, electromyography; NCS, nerve conduction study.