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. Author manuscript; available in PMC: 2018 Sep 11.
Published in final edited form as: Angew Chem Int Ed Engl. 2017 Aug 9;56(38):11545–11548. doi: 10.1002/anie.201707015

Table 1.

Optimization of reaction parameters.a

graphic file with name nihms915640u2.jpg
Entry L 1:2 Additive
(200 mol %)		 Yield
(%)b 		ee
(%)c
1 L1 2:1 LiBr 0 –
2 L2 2:1 LiBr 0 –
3 L3 2:1 LiBr 13 79
4 L3 2:1 BEt3 34 93
5 L3 1:1.2 BEt3 74 92
6 L3 1:2 BEt3 99 94

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[a]

Reactions performed on 0.1 mmol scale.

[b]

1H NMR yield based on internal standard.

[c]

Determined by chiral HPLC analysis.

[d]

TBD = 1,3,5-triazabicyclo[4.4.0]dec-5-ene.