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. 2017 Nov 6;216(11):3729–3744. doi: 10.1083/jcb.201611061

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© 2017 Zilberman et al.

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Figure 5. — pac-1 inhibits junctional CDC-42 activity. (A) Comparison of survival of embryos of the indicated genotypes, with the addition of control (empty vector) or pac-1 feeding RNAi. Values are the mean ± SEM from three independent experiments; p-value was calculated using a two-tailed t test with Welch’s correction. (B and C) CDC-42 biosensor localization in embryos treated with control (empty vector) RNAi or partial cdc-42 RNAi. (D) Quantification of CDC-42 biosensor intensity at epidermal AJs in control embryos (n = 20), embryos overexpressing mCherry-pac-1 (n = 15), or embryos overexpressing GAP-dead mCherry-pac-1(R984A) (n = 12). Individual data points from two independent experiments were pooled. Red bar and error bars are mean ± SD. P-values were calculated using a Mann-Whitney U test. ***, P ≤ 0.001; NS, P > 0.05. Bars, 5 µm.