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. 2017 Nov 6;216(11):3695–3712. doi: 10.1083/jcb.201703015

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© 2017 Simonetti et al.

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Figure 1. — Interactome of the retromer-linked SNX-BAR complex. (A) Schematic representation of the SILAC methodology and the approach used to filter and merge SILAC datasets. (B) Venn diagram showing the interactors of SNX5, SNX6, and SNX32. (C) Venn diagram showing the interactors of SNX1 and SNX2 together with the shared interactors between SNX5, SNX6, and SNX32 (those within the red demarcated area in B). (D) STRING analysis of SNX-BAR interactors. Interactors were compiled and subjected to STRING analysis. Each connecting line represents an interaction indicated by experimental or database evidence. Color of the node indicates presence of the protein in a specific subset of the SNX-BAR interactome. (E) GFP trap of GFP-tagged retromer-linked SNX-BARs, retromer, and the retromer-independent SNX4 and SNX8, each transiently transfected in HEK293T cells. Molecular masses are given in kilodaltons. IP, immunoprecipitation.