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. 2017 Nov 6;216(11):3551–3570. doi: 10.1083/jcb.201703152

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© 2017 Dhatchinamoorthy et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 2. — The kinetochore has higher copy numbers of Ndc80 and MIND subcomplexes in anaphase, whereas the Dam1 complex has similar copy number in G1 and anaphase. (a) Violin plot of copy numbers of the inner kinetochore proteins in G1 and anaphase. The horizontal middle line is the mean, and the box represents the SD. 50–173 clusters were used to calculate the copy number. (b) Violin plot showing copy number of the outer kinetochore proteins. Subunits in the MIND and Ndc80 subcomplexes nearly double in copy number in anaphase. 50–150 clusters were used to calculate the copy number. (c) Violin plot showing the copy number of the subunits of the Dam1 subcomplex with similar counts in G1 and anaphase. 50–280 clusters were used to calculate the copy number. For a–c, a two-tailed t test was used to test for statistical significance. (d) The ratio of kinetochore proteins in anaphase to G1 (n = 3) show that the subunits of the MIND and Ndc80 subcomplexes have higher copy number in anaphase as compared with the Dam1 subunits. Error bars represent SEM.