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. 2017 Nov 6;216(11):3453–3462. doi: 10.1083/jcb.201705168

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© 2017 Chang et al.

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Figure 5. — Schematic for how Ran–GTP regulates SAF activities required for mitotic spindle assembly. SAFs (e.g., NuMA, TPX2, and HURP) are suppressed by the Ran-governed transport factors Importin-α and -β. Ran–GTP modulates interaction between Importins and SAFs. Free SAFs that regulate distinct microtubule behaviors control organization of the mitotic spindle.