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. 2017 Oct 31;11:209. doi: 10.3389/fnbeh.2017.00209

Figure 3.

Figure 3

Challenging effects of Cocaine or Lithium Chloride (LiCl) reverse or promote the effects of D1/5R activation on mPFC. (A) A single dose of cocaine (Coc, 20 mg/kg, i.p) generates a positive conditioning to the associate, white compartment when animals are tested at 24 h (Sal vs. Coc p = 0.003, n = 18–19). (B) The infusion of the D1/5R agonist SKF 38393 in the mPFC after a single cocaine conditioning does not generate the aversive behavior observed at 7 days (Tukey post hoc, p(interaction) = 0.0478, n = 10). (C) A single dose of LiCl (150 mg/kg i.p.) induces an aversive conditioning shown at 24 h but not at 7 days (Sal vs. LiCl p = 0.0032 n = 9). (D) Animals infused with the D1/5R agonist SKF 38393 or vehicle in the mPFC region immediately after the conditioning in the black compartment paired with LiCl promotes an aversive behavior 7 days later (Tukey post hoc p(interaction) = 0.0137 n = 10–11). *p < 0.05.