Table 2.
Cell cycling gene dysregulations induced by miRNA binding.
| Protein | miRNA | miRNA status in drug resistance | Sample/cancer | Mechanism | Reference |
|---|---|---|---|---|---|
| CDK2 | miR-638 | Overexpressed | HL60, NB4, THP-1/APL | CDK2 downregulation prevents G1/S progression | Lin et al. (77) |
| CDK2 | miR-885-5p | Reduction | Patient samples, SH-EP, KELLY, IMR32, SK-N-BE(2)c, and HDN 33 cell lines/neuroblastoma | Reduced cycling promotes senescence | Afanasyeva et al. (78) |
| CDK2 | miR-372 | Reduced | HeLa/cervical cancer | Reduced cycling prevents cell growth | Tian et al. (79) |
| CDK2 | miR-188 | Reduced | CNE cells/nasopharyngeal carcinoma | G1/S arrest prevents cell cycling | Wu et al. (80) |
| Cyclin A1 | miR-372 | Reduced | HeLa/cervical cancer | Reduced cycling prevents cell growth | Tian et al. (79) |
| Cyclin D1 | miR-188 | Reduced | CNE cells/nasopharyngeal carcinoma | G1/S arrest prevents cell cycling | Wu et al. (80) |
| Cyclin D1 | miR-16 | Reduced | A549/lung cancer | G1 and G1/S arrest reduces proliferation | Liu et al. (81) |
| Cyclin D3 | miR-188 | Reduced | CNE cells/nasopharyngeal carcinoma | G1/S arrest prevents cell cycling | Wu et al. (80) |
| Cyclin D3 | miR-16 | Reduced | A549/lung cancer | G1 and G1/S arrest reduces proliferation | Liu et al. (81) |
| Cyclin A2 | miR-188 | Reduced | CNE cells/nasopharyngeal carcinoma | G1/S arrest prevents cell cycling | Wu et al. (80) |
| Cyclin E2 | miR-188 | Reduced | CNE cells/nasopharyngeal carcinoma | G1/S arrest prevents cell cycling | Wu et al. (80) |
| Cdk4 | miR-188 | Reduced | CNE cells/nasopharyngeal carcinoma | G1/S arrest prevents cell cycling | Wu et al. (80) |
| Cdk6 | miR-16 | Reduced | A549/lung cancer | G1 and G1/S arrest reduces proliferation | Liu et al. (81) |
| Cyclin E1 | miR-16 | Reduced | A549/lung cancer | miR-16 loss may lead to G1 and G1/S arrest reduces proliferation | Liu et al. (81) |
| E2F7 | miR-26a | Reduced | Patient samples, HL60, U937/APL | Downregulation of E2F7 reduces progression | Salvatori et al. (82) |
| P21 | miR-17-92 | Overexpressed | MLL transformed cells/AML | Downregulation of p21 promotes non-differentiation | Wong et al. (83) |
| E2F1 | miR-223 | Overexpressed | Patient samples, K562, U937/AML, CML | E2F1 downregulation contributes to non-differentiated cell cycle progression | Pulikkan et al. (84) |
miRNAs, microRNAs; APL, acute promyelocytic leukemia; CDK, cyclin-dependent kinase; AML, acute myeloid leukemia.