Table 3.
TAP1 expression in relation to molecular characteristics in CRC.
| TAP1 expression |
TAP1 expression |
|||||
| |
IRS Front ≤ 6 |
IRS Front > 6 |
P-valuea |
IRS Center ≤ 6 |
IRS Center > 6 |
P-valuea |
| Frequencies, n (%) | 268 (62.2) | 163 (37.8) | 311 (71.3) | 125 (28.7) | ||
| MSI screening status, n (%) | 0.784 | 0.219 | ||||
| MSI | 41 (61.2) | 26 (38.8) | 44 (65.7) | 23 (34.3) | ||
| MSS | 221 (63.0) | 130 (37.0) | 260 (73.0) | 96 (27.0) | ||
| CIMP status, n (%)b | 0.880 | 0.266 | ||||
| CIMP-negative | 130 (61.9) | 80 (38.1) | 160 (75.1) | 53 (24.9) | ||
| CIMP-low | 102 (63.4) | 59 (36.6) | 112 (68.7) | 51 (31.3) | ||
| CIMP-high | 34 (59.6) | 23 (40.4) | 38 (66.7) | 19 (33.3) | ||
| BRAFV600E, n (%) | 0.486 | 0.184 | ||||
| wild type | 227 (62.7) | 135 (37.3) | 267 (72.8) | 100 (27.2) | ||
| mutated | 36 (58.1) | 26 (41.9) | 40 (64.5) | 22 (35.5) | ||
| KRAS (codon 12, 13), n (%) | 0.336 | 0.333 | ||||
| wild type | 212 (61.3) | 134 (38.7) | 248 (70.9) | 102 (29.1) | ||
| mutated | 53 (67.1) | 26 (32.9) | 61 (76.3) | 19 (23.8) | ||
Abbreviations: MSI, microsatellite instability; MSS, microsatellite stable; CIMP, CpG island methylator phenotype.
a
χ2 test.
b
CIMP negative, no promoter hypermethylation; CIMP low, one to 5 genes methylated; CIMP high, 6 to 8 genes methylated.