Figure 1.

STAT1 deficient mice develop faster tumor growth and enhanced metastasis to the lungs. WT or STAT1^−/− mice were injected with 4T1.2 cells in the mammary tissue. (a) Primary breast tumor measurements in WT and STAT1^−/− mice during the course of the experiment. (b) Postmortem analysis of primary breast tumor weight in WT and STAT1^−/− mice. (c) Representative images and H&E sections of lungs isolated from WT and STAT1^−/− primary tumor bearing mice. (d) Counts of nodules per/lung in WT and STAT1^−/− mice. Data from 2 independent experiments with an n-value of 5–6 mice per group. *p = 0.05, **p = 0.01.