Table 2.

Genome-wide assessment of prostate cancer survival.

		PRACTICAL and BPC3		CONOR	All studies§
SNP CHR:BP	AllelesϮ MAF	Total number No of PC/deaths	HR (95% CI) P-value	HR (95% CI) P-value	HR (95% CI) P-value
rs190087062	G/A	2,416/704	2.83 (1.99–4.02)
1:115063785	0.02		6,5E-09
rs114997855	A/G	20,051/2,729	1.75 (1.44–2.13)	0.88 (0.42–1.85)	1.67 (1.38–2.03)
2:30622824	0.02		2,6E-08	0,73	1,20E-07
rs76010824	A/G	23,251/3,324	1.29 (1.18–1.41)	1.01 (0.76–1.35)	1.26 (1.16–1.38)
3:67442642	0.07		2,8E-08	0,94	1,10E-07
rs184342703	T/C	6,812/832	2.36 (1.73–3.20)
4:135989066	0.02		4,2E-08
rs192864713	G/A	1,738/464	3.54 (2.31–5.43)
5:27429220	0.01		7,3E-09
rs111414857	G/A	17,146/2,236	1.98 (1.56–2.50)
7:126639415	0.01		1,7E-08
rs149470135	A/T	4,725/599	3.09 (2.09–4.59)
8:86472701	0.01		2,0E-08
rs117643112	C/A	6,306/1,577	1.93 (1.53–2.43)
12:81746712	0.02		3,1E-08
rs140659849ʔ	A/G	2,702/271	3.00 (2.06–4.36)	0.75 (0.24–2.33)	2.61 (1.83–3.73)
X:50194937	0.01		9,6E-09	0,62	1,20E-07
rs723557ɣ	G/T	23,251/3,324	1.17 (1.10–1.24)	1.00 (0.84–1.19)	1.15 (1.09–1.22)
X:126653357	0.08		1,5E-07	0,98	6,10E-07

Abbreviations: CHR=Chromosome, BP=Base position (Genome build 37), MAF=Minor allele frequency, HR=Hazard ratio, 95% CI=95% confidence interval.

^ϮMinor allele/Major allele. Minor allele used as effect allele (major as reference) in analysis.

^§Meta-analysis between PRACTICAL, BPC3 and CONOR.

^ɣProxy for rs13440791 (p=2.7E-08 in PRACTICAL and BPC3).

^ʔProxy for rs190977150 (p=9.5E-09 in PRACTICAL and BPC3).