Table 1.
Comparison of Different Predictive Metrics for the First Published Chen et al. Data Set9
| Criteria | % Correct (Positive Predictive Value, PPV) | % DILI Missing (False Negative Rate, FNR) | % Accuracy (ACC) (True Positive + True Negative)/151 |
|---|---|---|---|
| Rule of Two | 95.3% | 61.7% | 55.0% |
|
| |||
| BDDCS Class 2 | 90.2% | 48.6% | 61.6% |
| BDDCS Class 2 + Dose ≥ 50mg | 94.1% | 55.1% | 58.9% |
| BDDCS Class 2+ Dose ≥ 100 mg | 93.8% | 57.9% | 57.0% |
|
| |||
| Dose ≥ 50mg | 83.5% | 15.0% | 77.5% |
| Dose ≥ 100mg | 85.6% | 22.4% | 74.8% |
|
| |||
| BDDCS Class (1 + 2) | 74.8% | 16.8% | 68.2% |
| BDDCS Class (1 + 2) + Dose ≥ 50mg | 87.4% | 29.0% | 72.2% |
| BDDCS Class (1 + 2) + Dose ≥ 100mg | 90.8% | 35.5% | 70.2% |
|
| |||
| BDDCS Class (2 + 4) | 89.4% | 44.9% | 63.6% |
| BDDCS Class (2 + 4) + Dose ≥ 50mg | 92.9% | 51.4% | 60.9% |
| BDDCS Class (2 + 4) + Dose ≥ 100mg | 92.5% | 54.2% | 58.9% |
|
| |||
| CLogP ≥ 3 | 76.1% | 52.3% | 52.3% |
| CLogP ≥ 3 +Dose ≥50mg | 91.7% | 58.9% | 55.6% |
|
| |||
| BDDCS Class 1 | 58.6% | 68.2% | 35.8% |
| BDDCS Class 3 | 51.9% | 86.9% | 29.8% |
| BDDCS Class 4 | 80.0% | 96.3% | 31.1% |