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Allosteric ligands discussed in this review. A) Histone peptides interacting with GCN5 and KDM5A, (un)modified as listed, respectively. B) I-CBP112 is a bromodomain ligand for p300 and CBP. C) MAML1 binds the CH3 domain of p300 to activate enzyme activity. D) SGC707 binds to the dimerization interface of PRMT3 to disengage the activation helix and inhibit activity.
