Table 1.

Epigenetic enzymes, their allosteric ligands, and functional effects.

Enzyme	Active Site	Ligand	Ligand Binding Site	Ligand Action
KDM5A	JmjC/N	H3(1-18) unmodified	PHD1	activate H3K4me3 demethylation
p300/CBP	HAT	MAML1 Proline-rich region	CH3	increase H4 acetylation and p300 target gene expression
p300/CBP	HAT	CBP112	Bromodomain	increase H3K18ac
GCN5	HAT	H3K14ac(1-18)	Bromodomain	increase H3K18ac
PRMT3	SAM-Dependent MTase	SGC707	Distal interface between SAM-Dependent MTase, α-Helix, and Dimerization Arm	decrease H4R3me2a