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. Author manuscript; available in PMC: 2017 Nov 7.
Published in final edited form as: Chem Rev. 2013 Dec 26;114(8):4206–4228. doi: 10.1021/cr4004488

Figure 11.

Figure 11

Sequence alignments of selected class I and class II glyoxalase I enzymes created using Clustal W2. Amino acids are colored by property (hydrophobic (red), acidic (blue), basic (purple), other (green)). Metal binding residues are highlighted in yellow. Residues marked with an asterisk (∗) are invariant; those marked by other symbols represent low (:) and moderate (.) variability. The N-terminal extension and additional loops found in class I enzymes are highlighted in blue. The S. cerevisiae sequence was truncated after 226 of 326 residues.