Extended Data Figure 9. Broad Hras activation and mutation-independent systems reveal a wide range of corrective abilities.
a, Representative phenotypes in LV-cre HrasG12V broad activation model (59% are hyperthickened and 10% are structurally deformed). b, Quantification of follicular bulge width demonstrates that Hras follicles are significantly hyperthickened during the first rest (P < 0.0001) and growth phases (P < 0.0001), but that hyperthickening is resolved by the second rest phase (P = 0.0860, n = 492 wild-type follicles, 550 Hras follicles, three mice per genotype). c, Haematoxylin and eosin images demonstrating regions of epidermal hyperplasia (upper arrowhead) and dermal cysts (lower arrowhead). d, Keratinized cyst resolves over time. e, Top: x–y view of macroscopic growth in Hras mouse demonstrates that hyperthickening and hyperkeratinization are resolved in 6 weeks. Hair follicles (A–C) are used as landmarks. Bottom: y–z view of macroscopic growth at starting (p38) and ending (p80) time points (n = 3 regressing macroscopic growths observed in two mice).