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. Author manuscript; available in PMC: 2018 Feb 17.
Published in final edited form as: Nature. 2017 Aug 2;548(7667):334–337. doi: 10.1038/nature23304

Figure 2. Wild-type cells are required for the active elimination of mutant cells.

Figure 2

a, Revisits of the same β-catenin outgrowth. b, c, β-Catenin/Wls outgrowth phenotypes (mean ± s.e.m., number of outgrowths = 168 Wls+/+ in three mice; n = 66 Wlsfl/+ in two mice; n = 233 Wlsfl/fl in four mice). d, Schematic of β-catenin and CDKN1b induction (top) and outgrowth revisits (bottom). e, Quantification of growth and regression (mean ± s.e.m., n = 70 outgrowths in four β-catenin/CDKN1b mice and n = 126 in four β-catenin mice). f, Dilated follicular cyst with stratified squamous epithelial lining (black arrow head) displaying keratinohyalin granules and dyskeratotic keratinocytes from β-catenin/CDKN1b. Scale bars, 50 µm.