Figure 3. Fate of regressing tissue is niche-dependent.

a, Quantification of growth and regression phases of outgrowths (mean ± s.e.m.). Pre-phenotypic plot (n = 73 outgrowths across three mice) accounts for hair follicles before outgrowth development. b, Outgrowth remaining cells are converted into extranumerary sebaceous gland lobe (left) or hair follicle (right). Extranumerary structures are outlined in blue. c, Quantification of the different fates of non-hair cycling epithelial outgrowths (mean ± s.e.m., n = 73 outgrowths). d, Representative images of distinct epidermal regions over time, after a high dose (2 mg) of tamoxifen (n = 4 mice). Insets show representative hair follicles and derived tumours at progressive time points. Scale bars, 50 µm.