Extended Data Figure 2. Developing mutant outgrowths are largely composed of a mixture of mutant and wild-type cells.

a, Percentage distribution of new bud composition, with 71% of developing outgrowths made up of a mixture of mutant and wild-type cells (n = 112 new buds across three mice). b, Representative budding outgrowths in tamoxifen-treated (200 µg) K19cre^ER;β-catn^flox(ex3) mice. All epithelial nuclei are labelled with K14–H2BmCherry (red). Nuclei of mutant cells are labelled with TCF–H2BGFP (green). All scale bars, 50 µm.