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The synergistic interaction between Sf1 SUMOylation and Dax1 controls the timing of X-zone regression. (A) Genetic depletion of Sf1 SUMOylation or Dax1 expression in mouse adrenal cortex delays the timing of X-zone regression by activating FAdE in postnatal adrenal glands. (B) SUMOylation of Sf1 enhances Dax1 binding to Sf1 protein and subsequent inhibition of FAdE activity in adrenocortical cells.
