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. 2017 Oct 15;144(20):3731–3743. doi: 10.1242/dev.151654

Fig. 1.

Fig. 1.

miR-290 cluster expression becomes localized to extraembryonic tissues following gastrulation. (A) At E7.5, the miR-290-mCherry reporter (red) is expressed in both embryonic and extraembryonic tissue. (B) At E8.5, the miR-290 mCherry reporter (red) is strongly expressed in yolk sac, chorion and ectoplacental cone, but not in the embryo. (C,D) At E10.5 and E15.5, miR-290 mCherry reporter (red) continues to be expressed in placenta and yolk sac but not in the embryo. (E,F) qRT-PCR results showing that miR-290 cluster expression changes in yolk sac and placental labyrinth at different time points, normalized to Sno202. B.F, bright field; EPC, ectoplacental cone; Ch, chorion; YS, yolk sac. Scale bars: 100 μm.