Figure 1.

Induction of Epidermal Anagen Hair Cycling in Skin

(A) Photomicrographs of mouse dorsal skin at day 7 and day 21 showing induction of anagen hair cycling in TRF-treated shaved skin. (B) Dermascopic images from insets in (A) of the dorsal mouse skin at day 7 and day 21. TRF induced anagen hair on day 21. (C) Photomicrograph of formalin-fixed, paraffin-embedded H&E-stained sections showing more anagen hair follicles with dermal papillae reaching the subcutaneous fat layer in TRF-treated sections at day 21. Scale bars, 500 μm. Inset: close-up of a hair follicle with outer root sheath (ORS), inner root sheath (IRS), cortex (C), and medulla (M). Hair follicles were quantified from H&E-stained sections. Data are mean ± SD (n = 6). *p < 0.001.