Figure 7.

β-Catenin Inhibition Arrested Inducible Anagen Hair Cycling

(A) IWR-1, a β-catenin inhibitor, significantly attenuated TRF-induced epidermal β-catenin (green) expression in the adult skin. Counterstained with DAPI (blue). Scale bars, 500 μm. β-Catenin signal was quantified and plotted graphically. Data are mean ± SD (n = 3; ^†p < 0.01). The dermal (der) and epidermal junctions are marked by a dashed line in the inset pictures. Scale bars, 20 μm. (B) IWR-1 inhibited TRF-induced translocation of β-catenin to the nucleus. Scale bar, 50 μm. (C) Proposed schematic diagram of TRF-induced hair folliculogenesis.