Table 2.
Prevalence of renal impairment* by demographic and clinical characteristics among 5,772 CHeCS hepatitis C viremic patients
| Variables | Overall n | eGFR*<30 n (%) | eGFR* 30–80 n (%) | eGFR*>80 n (%) | p-value |
|---|---|---|---|---|---|
| Total | 5722 | 133 (2.3) | 1788 (31.2) | 3851 (67.3) | |
| Birth year | |||||
| 1965 through 1984 | 1037 | 12 (1.2) | 177 (17.1) | 848 (81.8) | |
| 1955 through 1964 | 1978 | 39 (2.0) | 580 (29.3) | 1359 (68.7) | |
| 1945 through 1954 | 2267 | 65 (2.9) | 785 (34.6) | 1417 (62.5) | |
| ≤1944 | 490 | 17 (3.5) | 246 (50.2) | 227 (46.3) | <0.0001 |
| Male | 3252 | 73 (2.2) | 859 (26.4) | 2320 (71.3) | <0.0001 |
| Race | |||||
| Non-Hispanic White | 3549 | 27 (0.8) | 1103 (31.1) | 2419 (68.2) | |
| Non-Hispanic Black | 1484 | 100 (6.7) | 430 (29.0) | 954 (64.3) | |
| Other | 739 | 6 (0.8) | 255 (34.5) | 478 (64.7) | <0.0001 |
| Median Yearly Household Income | |||||
| <30k | 1320 | 56 (4.2) | 402 (30.5) | 862 (65.3) | |
| ≥30k and <50k | 2663 | 53 (2.0) | 797 (29.9) | 1813 (68.1) | |
| ≥50 k and <75k | 1313 | 14 (1.1) | 429 (32.7) | 870 (66.3) | |
| ≥75k | 347 | 4 (1.2) | 121 (34.9) | 222 (64.0) | |
| Unknown | 129 | 6 (4.7) | 39 (30.2) | 84 (65.1) | <0.0001 |
| Insurance | |||||
| Medicaid only | 722 | 23 (3.2) | 216 (29.9) | 483 (66.9) | |
| Medicare or Medicare plus | 1373 | 72 (5.2) | 514 (37.4) | 787 (57.3) | |
| Private | 3339 | 30 (0.9) | 974 (29.2) | 2335 (69.9) | |
| No insurance | 247 | 8 (3.2) | 55 (22.3) | 184 (74.5) | |
| Unknown | 91 | 029 | (31.9) 62 | (68.1) | |
| Hypertension | |||||
| Yes | 2448 | 114 (4.7) | 853 (34.8) | 1481 (60.5) | |
| No | 3274 | 19 (<0.01) | 935 (28.6) | 2370 (72.4) | <0.0001 |
| Diabetes | |||||
| Yes | 1463 | 70 (4.8) | 496 (33.9) | 897 (61.3) | <0.0001 |
| No | 4259 | 63 (1.5) | 1292 (30.3) | 2954 (69.4) | |
| Ever received HCV treatment** | 2082 | 34 (1.6) | 637 (30.6) | 1411 (67.8) | 0.029 |
| Latest Fib4 | |||||
| <1.6 | 2517 | 54 (2.1) | 730 (29.0) | 1733 (68.9) | |
| ≥1.6 and <2.5 | 1329 | 40 (3.0) | 443 (33.3) | 846 (63.7) | |
| ≥2.5 and <3.25 | 558 | 11 (2.0) | 203 (36.4) | 344 (61.6) | |
| ≥3.25 and ≤5.88 | 761 | 20 (2.6) | 248 (32.6) | 493 (64.8) | |
| >5.88 | 607 | 8 (1.3) | 164 (27.0) | 435 (71.7) | 0.0003 |
*
Renal function categorized by latest estimated glomerular filtration rate ([eGFR] measured in ml/min/1.73m2 [21,26]) during the period 2006–2013; all observation including eGFR censored at 30 days prior to the first receipt of dialysis
**
All treatment courses were without sustained viral response with analysis limited to currently viremic pateints