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. Author manuscript; available in PMC: 2017 Nov 7.
Published in final edited form as: Nat Rev Drug Discov. 2017 Jun 9;16(8):545–564. doi: 10.1038/nrd.2017.87

Figure 1. Mechanisms relevant for nociception and analgesia.

Figure 1

There are several targets in both peripheral neurons, and in the nociceptive synapse between glia, PNS and CNS neurons in the spinal dorsal horn, that provide interventional strategies for the development of analgesics. The figure summarizes some of the major targets that have been expanded upon in the text.