Table 2.
Neuropsychological assessments
| Neuropsychological Assessment (N) | SU Baseline Mean (SD) | NSU Baseline Mean (SD) | P-value | Annul change (SE) in SU group | Annual change (SE) in NSU group | P-value for group difference of annual change |
|---|---|---|---|---|---|---|
| MoCA total score (128) | 25.52 (3.99) | 25.05 (3.45) | 0.04* | −0.262 (0.064) | −0.435 (0.061) | 0.01* |
| DRS-2 total score (313) | 135.04 (10.00) | 134.00 (11.83) | 0.22 | −0.732 (0.212) | −1.64 (0.203) | 0.001* |
| Attention subscore | 35.62 (1.57) | 35.47 (2.04) | 0.61 | −0.070 (0.054) | −0.150 (0.048) | 0.35 |
| Initiation subscore | 34.83 (4.46) | 34.20 (5.20) | 0.95 | −0.458 (0.085) | −0.783 (0.082) | 0.002* |
| Construction subscore | 5.87 (0.60) | 5.72 (0.85) | 0.05* | −0.065 (0.020) | −0.096 (0.019) | 0.201 |
| Concept subscore | 36.40 (2.99) | 36.12 (3.43) | 0.48 | −0.015 (0.066) | −0.189 (0.063) | 0.04* |
| Memory subscore | 22.33 (3.32) | 22.48 (3.10) | 0.95 | −0.135 (0.055) | −0.326 (0.053) | 0.006* |
| LNS (279) | 9.38 (3.17) | 9.04 (3.02) | 0.14 | −0.223 (0.043) | −0.328 (0.042) | 0.06 |
| FAS (231) | 41.96 (15.79) | 37.96 (15.38) | 0.02* | −0.878 (0.164) | −0.961 (0.160) | 0.69 |
| Animals (269) | 17.70 (5.83) | 16.72 (5.90) | 0.04* | −0.461 (0.090) | −0.487 (0.088) | 0.82 |
| Trails A total time (85) | 49.34 (47.37) | 45.94 (25.47) | 0.21 | 0.237 (0.577) | 0.815 (0.594) | 0.27 |
| Trails B total time (85) | 101.34 (59.11) | 103.94 (63.57) | 0.008* | 4.05 (1.23) | 5.50 (1.23) | 0.24 |
| Symbol Digit Modalities Test (85) | 37.97 (9.43) | 37.44 (11.10) | 0.11 | −0.714 (0.191) | −0.885 (0.186) | 0.37 |
| BNT (274) | 54.99 (6.06) | 55.14 (4.91) | 0.97 | −0.106 (0.048) | −0.0872 (0.049) | 0.77 |
| Clock Drawing Scale (291) | 5.75 (1.43) | 5.32 (1.84) | 0.07 | −0.084 (0.028) | −0.093 (0.028) | 0.80 |
| JOLO (271) | 22.41 (5.67) | 22.05 (5.33) | 0.71 | −0.106 (0.094) | −0.335 (0.097) | 0.06 |
| HVLT-R Total (295) | 19.77 (6.24) | 19.63 (5.84) | 0.48 | −0.374 (0.088) | −0.387 (0.086) | 0.91 |
| HVLT-R Delayed Recall | 5.93 (3.22) | 5.98 (3.39) | 0.86 | −0.197 (0.053) | −0.224 (0.052) | 0.69 |
| HVLT-R Retention % | 68.73 (29.93) | 69.47 (33.09) | 0.92 | −1.15 (0.638) | −1.63 (0.627) | 0.54 |
| HVLT-R Recognition Discrimination | 8.88 (2.62) | 8.82 (2.43) | 0.58 | −0.097 (0.042) | −0.093 (0.041) | 0.94 |
*
Denotes that significance p≤0.05.