Table 1.
Hemodynamic Parameters in the Left Ventricle and in the Aorta 8 Weeks after Sham Operation and after TAC in C57BL/6 LDLr−/− Mice
| Control Sham | AAV8-LDLr Sham | Control TAC | AAV8-LDLr TAC | |
|---|---|---|---|---|
| Number of mice | 19 | 13 | 19 | 16 |
| Left Ventricle | ||||
| Peak systolic pressure (mm Hg) | 100 ± 1 | 103 ± 2 | 150 ± 8§§§ | 160 ± 9§§§ |
| End-diastolic pressure (mm Hg) | 2.15 ± 0.58 | 2.38 ± 0.35 | 3.64 ± 0.50 | 2.59 ± 0.84 |
| dP/dtmax (mm Hg/ms) | 9.76 ± 0.43 | 11.4 ± 0.3°° | 9.25 ± 0.47 | 11.1 ± 0.9* |
| dP/dtmin (mm Hg/ms) | −8.14 ± 0.31 | −10.2 ± 0.2°°° | −9.19 ± 0.55 | −10.5 ± 0.8 |
| τ (ms) | 5.32 ± 0.20 | 4.65 ± 0.13° | 5.70 ± 0.21 | 4.95 ± 0.21* |
| Heart rate (bpm) | 599 ± 11 | 610 ± 10 | 580 ± 20 | 622 ± 10 |
| Aorta | ||||
| Mean pressure (mm Hg) | 80.8 ± 1.5 | 82.1 ± 2.1 | 87.7 ± 3.8 | 97.9 ± 5.5§ |
| Systolic pressure (mm Hg) | 99.2 ± 1.6 | 101 ± 2 | 147 ± 8§§§ | 155 ± 11§§§ |
| Diastolic pressure (mm Hg) | 64.7 ± 2.0 | 64.0 ± 3.5 | 50.6 ± 4.4§ | 60.5 ± 7.0 |
Data are expressed as means ± SEM. °p < 0.05, °°p < 0.01, °°°p < 0.001 versus control sham; §p < 0.05, §§§p < 0.001 versus respective sham groups; *p < 0.05 versus control TAC.