Table 1. Basic clinicoathological parameters of the patients and their correlation with BRCA1/2 mutation status in breast cancers.
| Characteristics | All(n=70) (%) | Non-carriers(n=55) (%) | BRCA1/2 carrier(n=15) (%) | P |
|---|---|---|---|---|
| Age | ||||
| Median (range) | 50 (30-80) | 51 (30-80) | 46 (37-63) | 0.048 |
| ≤40 years | 15 (21.4) | 11 (20.0) | 4 (26.7) | 0.723 |
| >40 years | 55 (78.6) | 44 (80.0) | 11 (73.3) | |
| Menopause at diagnosis | 0.227 | |||
| Post-menopause | 33 (47.1) | 28 (50.9) | 5 (33.3) | |
| Pre-menopause | 37 (52.9) | 27 (49.1) | 10 (66.7) | |
| Histology | 0.577 | |||
| Ductal | 65 (92.9) | 50 (90.9) | 15 (100.0) | |
| Other | 5 (7.1) | 5 (9.1) | 0 (0.0) | |
| Tumor size (cm) | 0.319 | |||
| ≤2 | 19 | 17 (30.9) | 2 (13.3) | |
| >2 | 49 | 37 (67.3) | 12 (80.0) | |
| Unknow | 2 | 1 (1.8) | 1 (6.7) | |
| Lymph node metastasis | 0.386 | |||
| No | 44 (62.9) | 33 (60.0) | 11 (73.3) | |
| Yes | 26 (37.1) | 22 (40.0) | 4 (26.7) | |
| TNM stage | 0.888 | |||
| 0/I | 12 (17.1) | 10 (18.2) | 2 (13.3) | |
| II | 48 (68.6) | 37 (67.3) | 11 (73.3) | |
| III/IV | 10 (14.3) | 8 (14.5) | 2 (13.3) | |
| Pathological stage | 1.0 | |||
| I/II | 8 | 6 (10.9) | 2 (13.3) | |
| III | 55 | 43 (78.2) | 12 (80.0) | |
| Unkown | 7 | 6 (10.9) | 1 (6.6) | |
| bilateral breast cancer | 0.043 | |||
| No | 68 (97.1) | 55 (100.0) | 13 (86.7) | |
| Yes | 2 (2.9) | 0 (0.0) | 2 (13.3) |