Table 2. Univariate and multivariate Cox regression analysis of the six OS-related LUAD-SDGs and the six-gene signature.
| Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI of HR | P value | HR | 95% CI of HR | P value | |
| RP11-513N24.1 | 0.7601 | 0.6433—0.8982 | 0.0013 | 0.7733 | 0.6543—0.9140 | 0.0026 |
| gender | 1.0508 | 0.7569—1.4589 | 0.7672 | 0.991154 | 0.7089—1.3859 | 0.9586 |
| stage | 2.5857 | 1.8110—3.6919 | 1.71E-07 | 2.563875 | 1.7908—3.6707 | 2.72E-07 |
| smoke | 1.1947 | 0.9755—1.4631 | 0.0854 | 1.167386 | 0.9473—1.4385 | 0.1464 |
| age | 1.0686 | 0.9020—1.2660 | 0.4431 | 1.087631 | 0.9209—1.2845 | 0.3224 |
| RP11-206P5.2 | 0.6963 | 0.5915—0.8198 | 1.38E-05 | 0.7008 | 0.5908—0.8313 | 4.47E-05 |
| gender | 1.0508 | 0.7569—1.4589 | 0.7672 | 0.8792 | 0.6243—1.2382 | 0.4612 |
| stage | 2.5857 | 1.8110—3.6919 | 1.71E-07 | 2.5147 | 1.7578—3.5974 | 4.48E-07 |
| smoke | 1.1947 | 0.9755—1.4631 | 0.0854 | 1.1448 | 0.9291—1.4104 | 0.2042 |
| age | 1.0686 | 0.9020—1.2660 | 0.4431 | 1.0796 | 0.9122—1.2778 | 0.3731 |
| SFTPB | 0.737 | 0.6346—0.8559 | 0.0001 | 0.7627 | 0.6529—0.8909 | 0.0006 |
| gender | 1.0508 | 0.7569—1.4589 | 0.7672 | 1.0336 | 0.7403—1.4432 | 0.8459 |
| stage | 2.5857 | 1.8110—3.6919 | 1.71E-07 | 2.4546 | 1.7147—3.5138 | 9.29E-07 |
| smoke | 1.1947 | 0.9755—1.4631 | 0.0854 | 1.1212 | 0.9008—1.3955 | 0.3058 |
| age | 1.0686 | 0.9020—1.2660 | 0.4431 | 1.1153 | 0.9412—1.3215 | 0.2077 |
| CHIAP2 | 0.7585 | 0.6339—0.9075 | 0.0025 | 0.7845 | 0.6548—0.9399 | 0.0085 |
| gender | 1.0508 | 0.7569—1.4589 | 0.7672 | 1.0321 | 0.7392—1.4411 | 0.8529 |
| stage | 2.5857 | 1.8110—3.6919 | 1.71E-07 | 2.4762 | 1.7307—3.5427 | 6.99E-07 |
| smoke | 1.1947 | 0.9755—1.4631 | 0.0854 | 1.1744 | 0.9464—1.4572 | 0.1444 |
| age | 1.0686 | 0.9020—1.2660 | 0.4431 | 1.0878 | 0.9199—1.2863 | 0.3251 |
| BMP5 | 0.6858 | 0.5925—0.7938 | 4.25E-07 | 0.7268 | 0.6243—0.8461 | 3.9E-05 |
| gender | 1.0508 | 0.7569—1.4589 | 0.7672 | 0.9943 | 0.7121—1.3883 | 0.9732 |
| stage | 2.5857 | 1.8110—3.6919 | 1.71E-07 | 2.3439 | 1.6316—3.3672 | 4.1E-06 |
| smoke | 1.1947 | 0.9755—1.4631 | 0.0854 | 1.0986 | 0.8883—1.3588 | 0.3857 |
| age | 1.0686 | 0.9020—1.2660 | 0.4431 | 1.0760 | 0.9110—1.2710 | 0.3882 |
| MS4A15 | 0.7568 | 0.636—0.9007 | 0.0017 | 0.7801 | 0.6536—0.9312 | 0.006 |
| gender | 1.0508 | 0.7569—1.4589 | 0.7672 | 1.0126 | 0.7255—1.4133 | 0.9414 |
| stage | 2.5857 | 1.8110—3.6919 | 1.71E-07 | 2.4917 | 1.7418—3.5646 | 5.81E-07 |
| smoke | 1.1947 | 0.9755—1.4631 | 0.0854 | 1.1598 | 0.9359—1.4373 | 0.1755 |
| age | 1.0686 | 0.9020—1.2660 | 0.4431 | 1.0846 | 0.9190—1.2800 | 0.3367 |
| Risk score | 1.5815 | 1.3658—1.8313 | 9.02E-10 | 1.5129 | 1.2988—1.7624 | 1.05E-07 |
| gender | 1.0508 | 0.7569—1.4589 | 0.7672 | 0.9217 | 0.6595—1.2883 | 0.6333 |
| stage | 2.5857 | 1.8110—3.6919 | 1.71E-07 | 2.2685 | 1.5805—3.2558 | 8.87E-06 |
| smoke | 1.1947 | 0.9755—1.4631 | 0.0854 | 1.0906 | 0.8785—1.3539 | 0.4317 |
| age | 1.0686 | 0.9020—1.2660 | 0.4431 | 1.0922 | 0.9249—1.2898 | 0.2983 |